Daptomycin–Phosphatidylglycerol Domains in Lipid Membranes
نویسندگان
چکیده
منابع مشابه
Coarsening dynamics of domains in lipid membranes.
We investigate isothermal diffusion and growth of micron-scale liquid domains within membranes of free-floating giant unilamellar vesicles with diameters between 80 and 250 μm. Domains appear after a rapid temperature quench, when the membrane is cooled through a miscibility phase transition such that coexisting liquid phases form. In membranes quenched far from a miscibility critical point, ci...
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In the past two decades or so there has been considerable advance in our knowledge of membrane structure. The fluid mosaic model of Singer and Nicolson (1) has had great heuristic value in thinking about membrane topology. In this model both proteins and lipids are free to diffuse in the bilayer, implying a random organization of protein and lipid. However, experimental evidence in diverse type...
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Fluorescence digital imaging microscopy was used to study the lateral distribution of the lipid components in erythrocyte membranes. Intact erythrocytes labeled with phospholipids containing a fluorophore attached to one fatty acid chain showed an uneven distribution of the phospholipids in the membrane thereby demonstrating the presence of membrane domains. The enrichment of the lipotropic com...
متن کاملDiffusion of liquid domains in lipid bilayer membranes.
We report diffusion coefficients of micron-scale liquid domains in giant unilamellar vesicles of phospholipids and cholesterol. The trajectory of each domain is tracked, and the mean square displacement grows linearly in time, as expected for Brownian motion. We study domain diffusion as a function of composition and temperature and measure how diffusion depends on domain size. We find mechanis...
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ژورنال
عنوان ژورنال: Langmuir
سال: 2017
ISSN: 0743-7463,1520-5827
DOI: 10.1021/acs.langmuir.7b01841